Rocuronium attenuates oculocardiac reflex during squint surgery in children anesthetized with halothane and nitrous oxide
Identifieur interne : 001618 ( Main/Exploration ); précédent : 001617; suivant : 001619Rocuronium attenuates oculocardiac reflex during squint surgery in children anesthetized with halothane and nitrous oxide
Auteurs : N. Kapanovic [Croatie] ; M. Jukic [Croatie] ; M. Carev [Croatie] ; G. Kardum [Croatie] ; Z. Dogas [Croatie]Source :
- Acta anaesthesiologica scandinavica [ 0001-5172 ] ; 2004.
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- Pascal (Inist)
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English descriptors
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Abstract
Background: The oculocardiac reflex (OCR) may be activated during squint surgery. The aim of this study was to test whether rocuronium 0.4 mg kg-1 could reduce the frequency of OCR, and also whether a single dose of succinylcholine 1 mg kg-1 could affect the frequency of OCR during anesthesia with halothane in a nitrous oxide/oxygen mixture. Methods: A total of 161 ASA I children, 3-10 years old, undergoing elective surgery of the medial rectus muscle (MRM) were randomly assigned to three groups. Group R (n=51), received 04 mg kg-1 of rocuronium intravenously before endotracheal intubation. Group S (n=58) received 1 mg kg-1of succinylcholine. Group C (controls, n=52) received no relaxant. Oculocardiac reflex was defined as a reduction in heart rate (HR)>=15% and/or the appearance of any other arrhythmias, during manipulation of the MRM. Analysis of variance (ANOVA), chi-squared, Kruskal-Wallis, and Student's t-tests were used for statistical analysis; P< 0.05 was considered statistically significant. Results: In group R, OCR occurred in 15/51 (29%) of children, in group S in 31/58 (53%), and in group C in 23/52 (44%) (X2 = 6.46, P = 0.049). In group R, the incidence of arrhythmias such as nodal rhythms, supraventricular and ventricular premature beats was 6%, compared with 22% in group S and 19% in group C (X2= 6.01, P=0.040). However, there was no reduction in the occurrence of bradycardia (X2 = 0.16, P = 0.924)., Conclusion: Rocuronium reduced the frequency of OCR, mainly by reducing the incidence of supraventricular and ventricular premature beats.
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Jukic</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Anesthesiology and Intensive Care, University Hospital Split</s1><s2>Split</s2><s3>HRV</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Croatie</country><wicri:noRegion>Split</wicri:noRegion></affiliation></author><author><name sortKey="Carev, M" sort="Carev, M" uniqKey="Carev M" first="M." last="Carev">M. Carev</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Anesthesiology and Intensive Care, University Hospital Split</s1><s2>Split</s2><s3>HRV</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Croatie</country><wicri:noRegion>Split</wicri:noRegion></affiliation></author><author><name sortKey="Kardum, G" sort="Kardum, G" uniqKey="Kardum G" first="G." last="Kardum">G. Kardum</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department ofNeuroscience, University of Split Medical School</s1><s2>Split</s2><s3>HRV</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Croatie</country><wicri:noRegion>Split</wicri:noRegion></affiliation></author><author><name sortKey="Dogas, Z" sort="Dogas, Z" uniqKey="Dogas Z" first="Z." last="Dogas">Z. Dogas</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department ofNeuroscience, University of Split Medical School</s1><s2>Split</s2><s3>HRV</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Croatie</country><wicri:noRegion>Split</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0061565</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 05-0061565 INIST</idno><idno type="RBID">Pascal:05-0061565</idno><idno type="wicri:Area/PascalFrancis/Corpus">000489</idno><idno type="wicri:Area/PascalFrancis/Curation">000300</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000461</idno><idno type="wicri:doubleKey">0001-5172:2004:Kapanovic N:rocuronium:attenuates:oculocardiac</idno><idno type="wicri:Area/Main/Merge">001672</idno><idno type="wicri:Area/Main/Curation">001618</idno><idno type="wicri:Area/Main/Exploration">001618</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Rocuronium attenuates oculocardiac reflex during squint surgery in children anesthetized with halothane and nitrous oxide</title><author><name sortKey="Kapanovic, N" sort="Kapanovic, N" uniqKey="Kapanovic N" first="N." last="Kapanovic">N. Kapanovic</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Anesthesiology and Intensive Care, University Hospital Split</s1><s2>Split</s2><s3>HRV</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Croatie</country><wicri:noRegion>Split</wicri:noRegion></affiliation></author><author><name sortKey="Jukic, M" sort="Jukic, M" uniqKey="Jukic M" first="M." last="Jukic">M. Jukic</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Anesthesiology and Intensive Care, University Hospital Split</s1><s2>Split</s2><s3>HRV</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Croatie</country><wicri:noRegion>Split</wicri:noRegion></affiliation></author><author><name sortKey="Carev, M" sort="Carev, M" uniqKey="Carev M" first="M." last="Carev">M. Carev</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Anesthesiology and Intensive Care, University Hospital Split</s1><s2>Split</s2><s3>HRV</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Croatie</country><wicri:noRegion>Split</wicri:noRegion></affiliation></author><author><name sortKey="Kardum, G" sort="Kardum, G" uniqKey="Kardum G" first="G." last="Kardum">G. Kardum</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department ofNeuroscience, University of Split Medical School</s1><s2>Split</s2><s3>HRV</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Croatie</country><wicri:noRegion>Split</wicri:noRegion></affiliation></author><author><name sortKey="Dogas, Z" sort="Dogas, Z" uniqKey="Dogas Z" first="Z." last="Dogas">Z. Dogas</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department ofNeuroscience, University of Split Medical School</s1><s2>Split</s2><s3>HRV</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Croatie</country><wicri:noRegion>Split</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Acta anaesthesiologica scandinavica</title><title level="j" type="abbreviated">Acta anaesthesiol. scand.</title><idno type="ISSN">0001-5172</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Acta anaesthesiologica scandinavica</title><title level="j" type="abbreviated">Acta anaesthesiol. scand.</title><idno type="ISSN">0001-5172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anesthesia</term><term>Child</term><term>General anesthetic</term><term>Halothane</term><term>Muscle relaxant</term><term>Pediatrics</term><term>Strabismus</term><term>Surgery</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Strabisme</term><term>Chirurgie</term><term>Enfant</term><term>Halothane</term><term>Anesthésie</term><term>Myorelaxant</term><term>Pédiatrie</term><term>Anesthésique général</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term><term>Enfant</term><term>Pédiatrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: The oculocardiac reflex (OCR) may be activated during squint surgery. The aim of this study was to test whether rocuronium 0.4 mg kg<sup>-1</sup> could reduce the frequency of OCR, and also whether a single dose of succinylcholine 1 mg kg<sup>-1</sup> could affect the frequency of OCR during anesthesia with halothane in a nitrous oxide/oxygen mixture. Methods: A total of 161 ASA I children, 3-10 years old, undergoing elective surgery of the medial rectus muscle (MRM) were randomly assigned to three groups. Group R (n=51), received 04 mg kg<sup>-1</sup> of rocuronium intravenously before endotracheal intubation. Group S (n=58) received 1 mg kg<sup>-1</sup>of succinylcholine. Group C (controls, n=52) received no relaxant. Oculocardiac reflex was defined as a reduction in heart rate (HR)>=15% and/or the appearance of any other arrhythmias, during manipulation of the MRM. Analysis of variance (ANOVA), chi-squared, Kruskal-Wallis, and Student's t-tests were used for statistical analysis; P< 0.05 was considered statistically significant. Results: In group R, OCR occurred in 15/51 (29%) of children, in group S in 31/58 (53%), and in group C in 23/52 (44%) (X<sup>2</sup> = 6.46, P = 0.049). In group R, the incidence of arrhythmias such as nodal rhythms, supraventricular and ventricular premature beats was 6%, compared with 22% in group S and 19% in group C (X<sup>2</sup>= 6.01, P=0.040). However, there was no reduction in the occurrence of bradycardia (X<sup>2</sup> = 0.16, P = 0.924)., Conclusion: Rocuronium reduced the frequency of OCR, mainly by reducing the incidence of supraventricular and ventricular premature beats.</div></front></TEI><affiliations><list><country><li>Croatie</li></country></list><tree><country name="Croatie"><noRegion><name sortKey="Kapanovic, N" sort="Kapanovic, N" uniqKey="Kapanovic N" first="N." last="Kapanovic">N. Kapanovic</name></noRegion><name sortKey="Carev, M" sort="Carev, M" uniqKey="Carev M" first="M." last="Carev">M. Carev</name><name sortKey="Dogas, Z" sort="Dogas, Z" uniqKey="Dogas Z" first="Z." last="Dogas">Z. Dogas</name><name sortKey="Jukic, M" sort="Jukic, M" uniqKey="Jukic M" first="M." last="Jukic">M. Jukic</name><name sortKey="Kardum, G" sort="Kardum, G" uniqKey="Kardum G" first="G." last="Kardum">G. Kardum</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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